![]() Furthermore, the high expression of MACC1 induces stemness, migration, invasion, and metastasis. MACC1 promotes cell death, genome instability, sustaining proliferative signaling, and inflammation. Numerous research groups have acquainted its importance as a metastasis inducer, prognostic, and predictive biomarker for more than 20 different tumor entities, including CRC, breast cancer, and hepatocellular carcinoma. The high expression of this gene drops the metastasis-free survival rate and, correlatively, the overall survival rate of the patients drastically. One of the remarkable biomarkers, metastasis-associated in colon cancer 1 (MACC1), was discovered in 2009. Accordingly, it is crucial to identify novel biomarkers that can be used for metastasis prediction and simultaneously as a target of therapeutic interventions to treat patients at high risk for metastasis. Although recent studies report improvements in the early stages, the overall survival rate of patients in the late stages is less than 10%. One of the most common cancer types is colorectal cancer (CRC). Among them, 40% developed metastasis, and 10 million lost their lives. Only in 2020, 19 million patients were diagnosed with cancer. This study is, to our knowledge, the first identification of the effect of curcumin on the restriction of cancer motility, proliferation, and colony-forming ability by using MACC1 as a target.Ĭancer is one of the leading causes of death worldwide. We further showed the MACC1-dependent effect of curcumin on clonogenicity and wound healing. Curcumin reduced the MACC1 expression, restricted the MACC1-induced proliferation, and was able to reduce the MACC1-induced cell motility as one of the crucial steps for the distant dissemination of the tumor. In this study, we have investigated the effect of one of the promising natural products, curcumin, on MACC1 expression and MACC1-induced tumor-promoting pathways. Therefore, we have aimed to inhibit its expression by using natural products, which are recently the center of most studies due to their low side effects and good tolerability. Our previous studies have elucidated metastasis-associated in colon cancer 1 (MACC1) as a direct link to metastasis formation. Despite the whole improvement in the field of cancer medicine, the treatment options for the patient in the late stages are very restricted. Metastasis is the main reason for the high mortality rate of colorectal cancer (CRC) patients. ![]()
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March 2023
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